Fth1 protein
WebNov 12, 2015 · Knockdown of ISCU enhanced the binding of iron regulatory protein 1 (IRP1), a cytosolic Fe-S protein, to an iron-responsive element in the 5' UTR of ferritin heavy polypeptide 1 (FTH1) mRNA and subsequently reduced the translation of FTH1, a major iron storage protein. WebFTH1 / YBR207W Overview. Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; …
Fth1 protein
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WebWestern blot was conducted to examine the protein levels of GPX4, FTH1, and SLC7A11. (B) The band density of GPX4, FTH1, and SLC7A11 was quantified and normalized to control. (C) Immunofluorescence staining was conducted to examine the expression and localization of GPX4 (red), Scale bar = 50 μM. WebJun 14, 2016 · NM_002032.3(FTH1):c.*389A>G Genes: BEST1:bestrophin 1 [Gene - OMIM - HGNC] FTH1:ferritin heavy chain 1 [Gene - OMIM - HGNC] Variant type: single nucleotide variant Cytogenetic location: 11q12.3 Genomic location: Chr11: 61964338 (on Assembly GRCh38) Chr11: 61731810 (on Assembly GRCh37) Preferred name:
WebDec 28, 2024 · There is an obvious evidence that combination strategies with chemotherapy or other targeted therapies can enhance the antiproliferative effect, especially by circumventing drug resistance. 15, 40 In the present study, we developed an FTH1 protein-based system enabling co-delivery of the TmSm protein and YM155 to obviously inhibit … WebFTH1: Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. ... Transferrin receptor protein 1; Cellular uptake of iron ...
WebNov 12, 2015 · FTH1 functions as a major iron storage protein and TFRC regulates iron entry into cells. Therefore, p53-ISCU pathway would play an important role in the maintenance of iron homeostasis. Full size ... WebFTH1 protein was also overexpressed in patient's samples and correlated with the in vitro cytotoxic activity of cytarabine. Lastly, we demonstrated that chemotherapy induced an …
WebNov 3, 2014 · The iron storage protein ferritin is a complex of 24 ferritin light chain (FTL; 134790) and ferritin heavy chain (FTH1) subunits in ratios that vary in different cell types.FTH subunits exhibit ferroxidase activity, converting Fe(2+) to Fe(3+), so that iron may be stored in the ferritin mineral core, which prevents undesirable reactions of Fe(2+) with …
WebApr 4, 2024 · Enables iron ion binding activity. Acts upstream of or within iron ion transport. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hemochromatosis type 5. Orthologous to human … thackeray parsonWebMar 24, 2024 · In addition, HO-1 , iron storage protein 1 (FHT1) , and xCT also mediate the occurrence of ferroptosis. In this study, we observed that the levels of MELK, GPX4, GSH, FTH1, and xCT decreased, the levels of HO-1, ROS, and Fe 2+ increased after miR-21-5p was downregulated in HCC cells. Therefore, miR-21-5p can facilitate the ferroptosis of … thackeray partners dallasWebProtein structures GENERAL INFORMATION i General description of the gene and the encoded protein(s) using information from HGNC and Ensembl , as well as predictions … symmetry electronics ttiWebApr 3, 2024 · The protein expression of FTH1 was increased by Sch B (Figure 4(e)). Additionally, Sch B promoted the binding of NCOA4 to FTH1 in vitro (Figure 4(f)). Collectively, these data suggested that Sch B could induce iron overload by ferritinophagy in hepatic fibrosis. symmetry electronics a division of ttiWebBACKGROUND: An emerging MRI reporter, ferritin heavy chain (FTH1), is recently applied to enhance the contrast and increase the sensitivity of MRI in the monitoring of solid tumors. However, FTH1-overexpression-related cytotoxicity is required to be explored. METHODS: By using the Tet-Off system, FTH1 overexpression was semi-quantitativiely and ... symmetry electronics corpWebNov 16, 2024 · However, piRNA-mediated post-transcriptional gene regulation in human somatic cells is not well understood. We discovered a human piRNA (piR-FTH1) which has a complementary sequence in the ferritin heavy chain 1 (Fth1) mRNA. We demonstrated that expression of piR-FTH1 and Fth1 are inversely correlated in the tested tumor cell lines. thackeray rd reservoirsymmetry education