2024 Ggt1-cre

Ggt1-cre

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August undefined, 2024

WebFeb 5, 2012 · Here we show that the BMP receptor activin-like kinase 3 (Alk3) is elevated early in diseased kidneys after injury. We also found that its deletion in the tubular epithelium leads to enhanced TGF-β1-Smad family member 3 (Smad3) signaling, epithelial damage and fibrosis, suggesting a protective role for Alk3-mediated signaling in the kidney. WebNov 1, 2024 · Section snippets Mouse lines used and study approval. Fan1 loxP/loxP mice were bred with γGt1-Cre mice (#012841, Tg(Ggt1-cre)M3Egn/J) 28 to generate proximal tubule–specific Fan1 KO. γGt1-Cre expression in the proximal tubule was demonstrated by crossing γGt1-Cre mice with NuTRAP mice (Jackson Laboratories #029899, B6;129S6 …

Acute Kidney Injury Instigates Malignant Renal Cell …

WebApr 27, 2024 · Proximal tubule-specific loss of Sirt6 increases UUO-induced extracellular matrix deposition. (A) Representative sections of kidneys from sham-and UUO-operated Sirt6 flox/flox ; Ggt1-Cre -(WT) and ... WebAir Intake Screen - Big Rig World carries Genuine OEM and Aftermarket parts to repair your vehicle at the lowest prices. Brand: TRP TRPPC Unit of Measure: Each VMRS Code: … shiretoko in winter

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WebApr 27, 2024 · Renal fibrosis in wild type and PT-Sirt6KO (Sirt6 flox/flox; Ggt1-Cre +) mice was induced by UUO surgery. After seven days, histologic examination and Western blot analysis were performed to examine extracellular matrix (ECM) protein expression. We evaluated inflammatory cytokine and cell adhesion molecule expression after ureteral … WebNov 22, 2024 · We used an initial pair of GGT1-Cre primers shown in Figure 1B, which were 400 bp in size. PCR primer sequences are listed in Table 1. Murine model of cisplatin-induced nephrotoxic AKI. Cisplatin nephrotoxic AKI was induced in randomly distributed male and female Trip13 Stop/Stop and GGT1-Cre +/– Trip13 Stop/Stop mice (aged 8–12 … WebDec 28, 2005 · 1101 Highway 171, Graceville, FL 32440 is a 1,120 sqft, 3 bed, 1 bath home sold in 2015. See the estimate, review home details, and search for homes nearby. shiretoko hostel hanare

Proximal Tubular Cell–Specific Ablation of Carnitine …

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Webrenal/urinary system. increased kidney weight ( J:175630 ) • at 20 months of age. albuminuria ( J:175630 ) • in angiotensin II-treated mice. abnormal kidney physiology ( J:175630 ) • at 20 months of age, mice exhibit increased renal injury index with increased macrophage, neutrophil, and lymphocyte infiltration compared with wild-type mice. WebSTOCK Tg(Ggt1-cre)M3Egn/J. Stock No: 012841. Protocol 19476: Separated PCR Assay - Tg(Ggt1-cre)M3Egn. Version 3. 0. Notes. This assay will NOT distinguish hemizygous … shiretoko national park bearsWebApr 4, 2024 · Tg (Ggt1-cre)M3Egn - Renal & Urinary SystemRecombinase Activity Detail. The rat proximal promoter to Ggt1 was used in a transgene construct to drive the … quizlet live hack answers

"WebTg (Ggt1-cre/ERT2)1Pepe. Mutation details : 411 bp of the mouse Ggt1 promoter was used to drive expression of an inducible cre/ERT2fusion in the proximal tubule of the kidney. One founder was created with 50 to 70 copies of the transgene integrated into the X chromosome. ( J:137094 ) " - Ggt1-cre

Ggt1-cre

WebNov 27, 2024 · In Ggt1-Cre mice, Cre recombinase is expressed in RTECs 7–10 days after birth, and as a result Cre-mediated gene ablation is unlikely to influence normal renal development (32). Vgf PT−/− mice were indistinguishable from WT littermates and normal renal function was not evidently influenced by Vgf deficiency in RTECs ( Fig. S3 ). WebIn this study, we crossed Trp53 and Pten conditional knockout mice with Ggt1-Cre mice to generate a Ggt1-Cre; Trp53 LoxP/LoxP; Pten LoxP/LoxP; YFP LoxP/LoxP (GPPY) …

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WebGgt1 tm1a(EUCOMM)Wtsi: Name: gamma-glutamyltransferase 1; targeted mutation 1a, Wellcome Trust Sanger Institute: MGI ID: MGI:4432621: Gene: Ggt1 Location: Chr10:75397438-75422034 bp, + strand Genetic Position: Chr10, 38.55 cM Alliance: Ggt1 tm1a(EUCOMM)Wtsi page IMPC: Ggt1 gene page WebSCHEDULE G-1 (Form 5471) (December 2024) Cost Sharing Arrangement Department of the Treasury Internal Revenue Service Attach to Form 5471.

WebSep 4, 2024 · In Ggt1-Cre mice, Cre recombinase is expressed in RTECs 7–10 days after birth, and as a result Cre-mediated gene ablation is unlikely to influence normal renal development . Vgf PT−/− mice were indistinguishable from WT littermates and normal renal function was not evidently influenced by Vgf deficiency in RTECs ( Fig. S3 ). WebFeb 1, 2024 · Additionally, quantitative proteomics and validated studies showed HMGCS2, a key enzyme for ketone synthesis, was increased in GGT1-cre DcR2 f/f mice compared with WT. And the levels of urinary and serum β-hydroxybutyrate were higher in GGT1-cre DcR2 f/f mice, suggesting DcR2 affects the synthesis of β-hydroxybutyrate through …

WebMar 13, 2024 · The Ggt1-Cre mice have a mix of BALB/cJ and C57BL/6 background. Animal models of acute kidney injury Given that AKI is associated with distinct disease conditions, multiple mouse models have been developed. 20 Ischemia, cisplatin, and rhabdomyolysis-associated AKI was triggered in male mice aged 8–12 weeks using … WebMay 15, 2024 · Ggt1-Cre mice were provided by Eric Neilson, Northwestern University (Chicago, IL), and described previously . The Ggt1 promoter is predominantly expressed …

WebNov 16, 2024 · Transgenic B6.Cg-Tg(Ggt1-cre)M3Egn/J mice that expressed Cre recombinase under the control of gamma-glutamyltransferase 1 (Ggt1) promoter …

WebApr 21, 2024 · l Ggt1-Cre mice were crossed with ROSA mT/mG mice to generate transgenic mice that express membrane-localized EGFP in renal tubular epithelial cells. … shiretoko national park nature centerhttp://www.informatics.jax.org/allele/allgenoviews/MGI:3811269 shiretoko national park japan windows 10WebSoftware to open or convert GT1 files. You can open GT1 files with the following programs: GenuTax Standard by GenuSource Consulting Inc. Free File Viewer Pro. quizlet literary termsWebline expressing Cre recombinase under the control of the Ggt1 promoter (28). As indicated in Figure 1A, to generate a renal prox-imal tubule–specific -KO mouse line (Pten ptKO), we crossed Pten this Ggt1-Cre mouse with Pten exon 5–floxed mice (Ptenfl/fl); exon 5 encodes the essential phosphatase core domain of the PTEN protein (27). shiretoko drift ice walk tourWebGgt1-Cre mice were crossed with FAN1 loxP/loxP mice to inactivate FAN1 expression in kidney proximal tubules. Kidney injury was induced by cisplatin administration (5 weekly injections of 2 mg/kg) or unilateral ureteral obstruction (UUO). Histological analysis was performed using hematoxylin and eosin, periodic acid–Schiff, or Masson’s ... quizlet live join code now bing abhttp://www.informatics.jax.org/recombinase/specificity?id=MGI:3811269&system=renal+%26+urinary+system quizlet live hack no downloadWebJan 13, 2024 · Transgenic B6.Cg-Tg(Ggt1-cre)M3Egn/J mice that express. cre under the control of Ggt1 promoter were purchased. from The Jackson Laboratory. The GeneBank Accession. Number for UCP2 is … shiretoko national park tour