2024 Pdgfra-creert2

Pdgfra-creert2

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SpletFig1. Cre-mediated recombination in the large and small intestine of Pdgfra Cre/+; Rosa26 tdTomato/+ mouse.. Fig2. Cre-mediated recombination in the retina of Pdgfra Cre/+; Rosa26 tdTomato/+ mouse.. Fig3. Detection of tdTomato(red) in various tissues of Pdgfra Cre/+; Rosa26 tdTomato/+ mice. Tdtomato can be detected in the brain, retina, pituitary gland, … Splet01. dec. 2010 · We administered tamoxifen to Pdgfra-CreERT2:Rosa26R-YFP mice to induce yellow fluorescent protein (YFP) expression in PDGFRA/NG2 cells and their differentiated progeny. We subsequently induced EAE and observed a large (>4-fold) increase in the local density of YFP+ cells, >90% of which were oligodendrocyte lineage …

PDGFRα and αSMA mark two distinct mesenchymal cell …

Splet14. sep. 2016 · In the central nervous system (CNS) platelet derived growth factor receptor alpha (PDGFRα) is expressed exclusively by oligodendrocyte progenitor cells (OPCs), … SpletA TdTomato-expressing cell (red, arrow) migrates along a vessel (green, outlined by dotted line) at the edge of a 1.5-dpl lesion (Supplementary Video 1). e, Frequency of PDGFRα⁺ OPC clusters at ... how to get to the excel centre london

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SpletThe PDGFRA gene provides instructions for making a protein called platelet-derived growth factor receptor alpha (PDGFRA), which is part of a family of proteins called receptor … SpletPDGFRA, i.e. platelet-derived growth factor receptor A, also termed PDGFRα, i.e. platelet-derived growth factor receptor α, or CD140a i.e. Cluster of Differentiation 140a, is a … Splet27. jul. 2024 · As a proof of principle that the PDGFRβ - P2A - CreER T2 mouse line is an efficient tool to drive genetic modifications in perivascular cells, we used it to specifically … how to get to the excel menu

018280 - Strain Details - The Jackson Laboratory

SpletFig1. Cre-mediated recombination in the large and small intestine of Pdgfra Cre/+; Rosa26 tdTomato/+ mouse.. Fig2. Cre-mediated recombination in the retina of Pdgfra Cre/+; … Splet06. apr. 2024 · (A) Whole-mount images of SI from Pdgfra CreERT2;R26R mT/mG mice, where Cre-expressing cells convert ubiquitous tdTom fluorescence (red) to eGFP signal (green), counterstained for F-actin (phalloidin, white). 30 μm z stack overlay. The dashed box is enlarged to the right and the crypt in that image is marked with a dashed white line. johns hopkins university homewood campusSplet04. sep. 2024 · In the normal lungs during alveologenesis, using a BAC transgenic Pdgfra-creERT2 line in lineage tracing, it was reported that Pdgfra+ cells give rise to both … how to get to the factory reset screen

"Splet04. sep. 2024 · This differs from the results from a recent lineage tracing study using a Pdgfra-CreERT2 BAC transgenic line, which showed that lineaged cells gave rise to more lipofibroblasts than myofibroblasts at the same stage (P7) (Ntokou et al., 2015). The difference of the results may be due to differences in the cell populations that are … " - Pdgfra-creert2

Pdgfra-creert2

Supplementary Figure 1. Generation and characterization of …

SpletTo investigate the role of macroautophagy/autophagy in AT fibrogenesis, we used Pdgfra-CreErt2 transgenic mice to create conditional deletion of Atg7 alleles in AT progenitor cells (atg7 cKO) and examined sex-dependent, depot-specific AT remodeling in high-fat diet (HFD)-fed mice.

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SpletGraph a shows numbers of PDGFRA+ (immunolabelled) OLPs in the CC and motor cortex of Pdgfra- CreER T2 / Rosa26-YFP mice at different times post-tamoxifen (one treatment Splet19. mar. 2024 · Pdgfra-CreERT2 mice were a kind gift from Bill Richardson (University College London, London, UK). Fra-2 Tg mice were kindly provided by Erwin Wagner (Research Institute of Molecular Pathology-IMP, Vienna, Austria). We appreciate excellent technical assistance by Thomas Fuchs, Visnja Bubalo, Alexandra Treitler, and Tatjana …

Splet23. apr. 2014 · The discovery of stem and progenitor cells in the adult mammalian heart has added a vital dimension to the field of cardiac regeneration. Cardiac-resident stem cells are likely sequestered as reserve cells within myocardial niches during the course of embryonic cardiogenesis, although they may also be recruited from external sources, such as bone … SpletMutation details: A mouse PAC clone (RPCI21-546M3) containing the Pdgfra gene was modified by the insertion of a tamoxifen-inducible cre recombinase gene into exon 2 …

SpletBy using this site, you agree to our Terms and Conditions Got it! Splet07. dec. 2015 · In the present study, the Pdgfra gene was systemically inactivated in adult mouse (α-KO mouse) and the role of PDGFRα was examined in the subcutaneously …

Splet07. feb. 2024 · Summary. This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens …

SpletPDGF receptor α (PDGFRα) is expressed specifically in the embryonic day 7.5 (E7.5) mesoderm and in the E9.5 neural crest among other tissues. PDGFRα-expressing cells … johns hopkins university hr phone numberSplet15. mar. 2024 · Fosl2tg; Pdgfra-CreERT2; tdTomatoﬂox, Fosl2tg; Acta2-CreERT2; tdTomatoﬂox, and littermate controls were eutha-nized, and lungs harvested at 20 wk of … johns hopkins university hubSpletSham and overloaded mesenchymal progenitors from Control (Pdgfra-CreERT2) or cdKO (Pdgfra-CreERT2::Yap1 flox/flox ::Taz flox/flox) were used for RNA-seq analysis. Contributor(s) Kaneshige A, Kaji T, Yasuyuki O, Fukada S: Citation(s) 34856120: Submission date: Dec 08, 2024: Last update date: Feb 18, 2024: johns hopkins university immunology phdSpletThe data suggest that Pdgfrα-CreERT2 transgenic mice can be used to achieve robust recombination in OPCs, while having a minimal effect on most PDGFRα+ cell populations outside of the CNS. In the central nervous system (CNS) platelet derived growth factor receptor alpha (PDGFRα) is expressed exclusively by oligodendrocyte progenitor cells … johns hopkins university investment officeSplet10. apr. 2024 · Aging is associated with a loss of blood stem cell fitness in part due to defects in stem cell-supportive niches. Here, the authors demonstrate that restoring niche function by treatment with ... how to get to the face shrine links awakeningSplet11. apr. 2024 · Liver sinusoidal endothelial cells play pivotal roles in liver function and influences the development of liver fibrosis. This study revealed the molecular mechanism by which liver sinusoidal endothe... johns hopkins university insuranceSpletA transgenic mouse line, Pdgfra-CreERT2, allowed temporally-controlled, permanent activation of YFP expression in PDGFRa-expressing OLPs and their differentiated progeny in the Rosa26-YFP reporter background. In vivo BrdU labelling and fate mapping of YFP-positive cells revealed that, in the corpus callosum, approximately half of the OLPs were ... johns hopkins university ib requirements